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—Dr Naumann has made an interesting observation that deserves consideration by all physicians who see patients with herpes zoster ophthalmicus.The reactivation of the virus within the trigeminal ganglion probably occurs sporadically throughout life, yet host-defense mechanisms determine the full manifestation of the reactivation. The occurrence of herpes zoster ophthalmicus is specifically associated with advancing age, immunosuppressive therapy, irradiation, local trauma, and cancer (lymphoma being especially frequent).In our series, the associated tumors were, for the most part, in the distant past. Two patients had malignant astrocytomas of the brain that were partially removed several months earlier. These tumors were not in the vicinity of the involved trigeminal ganglion and the patient never had clinical evidence of specific involvement of this area. The patient with the meningioma was still hospitalized after undergoing surgery for a partial resection of the tumor on the opposite side of the skull. In
Liesegang TJ, Womack LW. Benign Intracranial Tumors and Zoster Ophthalmicus-Reply. Arch Ophthalmol. 1984;102(2):195. doi:10.1001/archopht.1984.01040030149013