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February 1984

Diffuse Disseminated AtheroembolismThree Cases With Neuro-ophthalmic Manifestation

Author Affiliations

From the Department of Ophthalmology, University of Connecticut, Farmington (Dr Coppeto); the Departments of Ophthalmology, Neurology, and Anatomy, Boston University School of Medicine, (Dr S. Lessell); the Department of Neurology, Harvard Medical School, Boston (Dr I. Lessell); and the Departments of Medicine (Dr Greco) and Laboratory Medicine (Dr Eisenberg), Yale University School of Medicine, New Haven, Conn.

Arch Ophthalmol. 1984;102(2):225-228. doi:10.1001/archopht.1984.01040030175020

• Neuro-ophthalmic manifestations led to the diagnosis of diffuse disseminated atheroembolism (DDA) in three men whose systemic symptoms had remained unexplained for years. The cholesterol emboli that cause DDA originate from friable plaques in the aorta and great vessels. Ophthalmologists should be alert to the diagnosis of DDA in patients with elevated ESRs, stroke, transient amaurosis, or. cholesterol emboli in the fundi. Early diagnosis is important because arteriography, endarterectomy, and anticoagulation seem to increase the risk of serious, even fatal, embolization in these patients.