• We diagnosed Whipple's disease from the vitreous aspirate of two patients who underwent vitrectomies. In one case, the vitrectomy specimen would have indicated the diagnosis three years before the jejunal biopsy was performed had the appropriate PAS stain been used. In the second case, the PAS-positive macrophages were identified at the time of surgery.
Durant WJ, Flood T, Goldberg MF, Tso MOM, Pasquali LA, Peyman GA. Vitrectomy and Whipple's Disease. Arch Ophthalmol. 1984;102(6):848-851. doi:10.1001/archopht.1984.01040030668014