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Article
June 1984

Ceftazidime Concentrations in Human Aqueous Humor

Author Affiliations

From the Departments of Medicine (Dr Axelrod) and Ophthalmology (Drs Kochman, Horowitz, and Youngworth), St Luke's-Roosevelt Hospital Center, New York.

Arch Ophthalmol. 1984;102(6):923-925. doi:10.1001/archopht.1984.01040030743035
Abstract

• Two grams of ceftazidime was given to 25 patients before cataract surgery. Mean aqueous humor concentrations of 2.8, 3.2, 3.39, and 1.94 μg/mL were observed 30 minutes and 1, 2, 4, and 6 hours, respectively, after administration of the drug. These concentrations are many times higher than the minimum inhibitory concentration (MIC) of ceftazidime against 90% (MIC90) of isolates of Escherichia coli, Klebsiella sp, Proteus mirabilis, and indole-positive Proteus sp. The peak aqueous humor level was also equivalent to or slightly higher than the MIC90 for Pseudomonas aeruginosa.

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