• Two grams of ceftazidime was given to 25 patients before cataract surgery. Mean aqueous humor concentrations of 2.8, 3.2, 3.39, and 1.94 μg/mL were observed 30 minutes and 1, 2, 4, and 6 hours, respectively, after administration of the drug. These concentrations are many times higher than the minimum inhibitory concentration (MIC) of ceftazidime against 90% (MIC90) of isolates of Escherichia coli, Klebsiella sp, Proteus mirabilis, and indole-positive Proteus sp. The peak aqueous humor level was also equivalent to or slightly higher than the MIC90 for Pseudomonas aeruginosa.
Axelrod JL, Kochman RS, Horowitz MA, Youngworth L. Ceftazidime Concentrations in Human Aqueous Humor. Arch Ophthalmol. 1984;102(6):923-925. doi:10.1001/archopht.1984.01040030743035