• Phenylephrine hydrochloride eyedrops induce vasoconstriction through α-adrenergic mechanisms. Ten subjects underwent a 46% reduction in conjunctival Po2 when 2.5% phenylephrine eyedrops were administered. Compared with a control group, this reduction was significant. The induced conjunctival hypoxia lasted about 80 minutes. These findings suggest a number of clinical implications.
Isenberg SJ, Green BF. Effect of Phenylephrine Hydrochloride on Conjunctival Po2. Arch Ophthalmol. 1984;102(8):1185-1186. doi:10.1001/archopht.1984.01040030963026