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August 1984

Intravitreal Ceftriaxone in a Rabbit ModelDose- and Time-Dependent Toxic Effects and Pharmacokinetic Analysis

Author Affiliations

From the Departments of Medicine (Drs Shockley and Rissing) and Ophthalmology (Drs Jay, Friberg, A. M. Aziz, and M. Z. Aziz), Veterans Administration Medical Center and the Medical College of Georgia, Augusta.

Arch Ophthalmol. 1984;102(8):1236-1238. doi:10.1001/archopht.1984.01040031006037

• Ceftriaxone's toxic effects were assessed in albino rabbits after intravitreal injection. Doses up to 5 mg did not alter the B-wave amplitude. Following 7.5-and 20-mg doses, B-wave amplitude ratios were depressed at 24 hours and normal at seven and 14 days. A 50-mg dose caused a temporarily flat B-wave 24 hours after injection. At two weeks this ratio exhibited a moderate increase but remained 2 SDs below the mean preinjection ratio. Eyes receiving up to 20 mg were normal histologically at 14 days. A 50-mg dose induced generalized retinal edema and disruption of the retinal layers 24 hours after injection; at two weeks there were no histologic changes in the retina. Immediately after a 2-mg intravitreal injection, vitreous ceftriaxone levels were 1,345 ± 4.9 mg/L; by 72 hours they had decreased to 17.6 ± 1.4 mg/L. The mean peak aqueous level was 80.2 ± 12.2 mg/L at 72 hours.