• The oscillatory potential (OP) amplitudes of the electroretinogram (ERG) were determined in a group of 85 diabetic patients entering the Early Treatment Diabetic Retinopathy Study (ETDRS). The rate of progression among nonphotocoagulated eyes to the Diabetic Retinopathy Study high-risk characteristics (DRS-HRC) during a ten- to 40-month follow-up period was determined. Progression occurred in 19 of 85 eyes at risk. Those eyes with abnormal OP amplitudes (≤75 μV) at study entry had a tenfold higher rate of progression to DRS-HRC than did eyes with normal amplitudes (>75 μV). Although the level of retinopathic severity at study entry was a significant factor in the rate of subsequent progression, the amplitudes of the OPs remained a significant risk factor even after correcting the initial retinopathic level. The ERG seems to be a useful clinical tool in predicting the rate of progression of diabetic retinopathy. The reduction in OP amplitudes probably is a quantitative measure of the degree of overall inner layer retinal ischemia.
Bresnick GH, Korth K, Groo A, Palta M. Electroretinographic Oscillatory Potentials Predict Progression of Diabetic RetinopathyPreliminary Report. Arch Ophthalmol. 1984;102(9):1307-1311. doi:10.1001/archopht.1984.01040031057023