• Butyl-2-cyanoacrylate (Histoacryl Blue) tissue adhesive successfully sealed three cases of CSF leaks encountered during orbital surgery. The application of tissue adhesive was followed by prompt cessation of leak. We have found this tissue adhesive to be a valuable technical adjunct in the intraoperative management of this difficult problem and have not seen any general or local toxic reaction to the material.
Tse DT, Panje WR, Anderson RL. Cyanoacrylate Adhesive Used to Stop CSF Leaks During Orbital Surgery. Arch Ophthalmol. 1984;102(9):1337-1339. doi:10.1001/archopht.1984.01040031087031