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September 1984

Actin Filaments in Contracting Preretinal Membranes

Author Affiliations

From the Department of Ophthalmology, University of Wisconsin Medical School (Drs Wallow and Stevens and Mss Bindley and Wilson), and the Muscle Biology Laboratory, University of Wisconsin-Madison (Dr Greaser).

Arch Ophthalmol. 1984;102(9):1370-1375. doi:10.1001/archopht.1984.01040031112036

• In 14 patients, preretinal membranes, causing retinal traction and severe visual impairment, were removed by vitrectomy and evaluated by light and electron microscopy using myosin subfragment-1 to stain actin filaments. Eight membranes were of vascular origin, six of nonvascular origin. All but one contained bundles of oriented actin filaments within a number of their nonvascular stroma cells, suggesting that the contractile protein action may have been involved in their clinically observed contraction.