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October 1984

Vascular Endothelial Cell Growth Inhibitor of Normal and Pathologic Human Vitreous

Author Affiliations

From the Department of Fine Structure Research, Boston Biomedical Research Institute, and the Department of Ophthalmology, Harvard Medical School, Boston (Dr Jacobson), and the Department of Ophthalmology, University of Toronto (Dr Basu and Mr Hasany).

Arch Ophthalmol. 1984;102(10):1543-1545. doi:10.1001/archopht.1984.01040031259031

• Normal and pathologic human vitreous have been analyzed for the presence of a low—molecular weight inhibitor of aortic endothelial cell proliferation. Vitreous was subjected to gel chromatography and the material appearing in the retarded volume (<13,000 daltons) was tested for its ability to inhibit tritiated thymidine incorporation into DNA by calf aortic endothelial cells. Depending on the sample of vitreous analyzed, one or more fractions showing inhibitory activity were identified in each case.