Dreyer and Gass1 have expanded clinical and epidemiologic characteristics of a uveitis syndrome, initially described in 1973 by Nozik and Dorsch,2 that is characterized by punched-out chorioretinal lesions, submacular choroidal neovascular net, disciform lesion, vitritis, and anterior segment inflammation. Although this disease in many ways mimics presumed ocular histoplasmosis, the clinical and epidemiologic characteristics clearly differentiate the two disorders. The features differentiating this uveitis syndrome from acute multifocal placoid pigment epitheliopathy (AMPPE), diffuse unilateral subacute neuroretinitis (DUSN), and birdshot (vitiliginous) choroiditis are less clear.
See also p 1776.
Although all the aforementioned conditions (except DUSN) are characterized by small, circumscribed chorioretinal lesions and a disciform process, they are differentiated from presumed ocular histoplasmosis by the symptomatic onset of the chorioretinal lesions, their smaller size and more irregular configuration, presence of vitreous cells, and signs of anterior segment inflammation. Of the latter group of disorders, only DUSN has
Ganley JP. Epidemiology of Presumed Ocular Histoplasmosis. Arch Ophthalmol. 1984;102(12):1754-1756. doi:10.1001/archopht.1984.01040031418014