• The use of carbonic anhydrase inhibitors (CAIs) was associated with mean increases in whole-blood zinc levels of 82 μg/dL and 70 μg/dL, respectively, in a cross-sectional survey and in a prospective study of patients with glaucoma. The time course of the increase suggests that CAIs induce reticulocyte synthesis of carbonic anhydrase.
Walker AM, Arrigg C, Hertzmark E, Epstein DL. Carbonic Anhydrase Inhibitors Induce Elevations in Human Whole-Blood Zinc Levels. Arch Ophthalmol. 1984;102(12):1785-1787. doi:10.1001/archopht.1984.01040031449020