• To determine the combined ocular hypotensive effect of topical betaxolol hydrochloride and oral acetazolamide, we conducted a three-week clinical trial of the concurrent administration of the two drugs. One drop of betaxolol hydrochloride 0.5% every 12 hours effected a mean reduction in outflow pressure from base-line of 27.3%. When given topically to both eyes of a patient pretreated with oral acetazolamide (500 mg every 12 hours), betaxolol caused an additional mean outflow pressure decrease of 17.6%. Acetazolamide, 500 mg orally every 12 hours, produced a mean outflow pressure reduction from baseline of 42.5%. When added to the therapy regimen of a patient already receiving topical betaxolol, oral acetazolamide caused an additional mean outflow pressure decrease of 35.1%. Our study supports the clinical usefulness of concurrent administration of betaxolol and acetazolamide to lower intraocular pressure.
Smith JP, Weeks RH, Newland EF, Ward RL. Betaxolol and AcetazolamideCombined Ocular Hypotensive Effect. Arch Ophthalmol. 1984;102(12):1794-1795. doi:10.1001/archopht.1984.01040031458022