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February 1985

An Antimelanoma Monoclonal Antibody and the Histopathology of Uveal Melanomas

Author Affiliations

From the Departments of Pathology (Dr Folberg and Ms Arbizo) and Research (Dr Donoso), Wills Eye Hospital and Thomas Jefferson University; the Department of Pathology and Laboratory Medicine, University of Pennsylvania (Drs Atkinson and Ernst); and the Wistar Institute of Anatomy and Biology (Drs Atkinson and Herlyn), Philadelphia. Dr Folberg is now with the University of Iowa Hospitals and Clinics, Iowa City.

Arch Ophthalmol. 1985;103(2):275-279. doi:10.1001/archopht.1985.01050020127035

• Monoclonal antibody ME491 identifies a cutaneous melanoma-associated antigen in formaldehyde-fixed, paraffinembedded tissues. This antibody was applied to tissue sections from 79 cases of formaldehyde-fixed, paraffin-embedded uveal melanomas. Sixty-nine (87.3%) of the 79 cases showed staining by monoclonal antibody ME491, thus demonstrating an antigen shared by cutaneous and uveal melanomas. No relationship between the staining pattern and the patient outcome was detected. Twelve (85.7%) of the 14 cases in which balloon cells were present stained with the antibody. The antibody stained the long posterior ciliary nerve in 12 (38.7%) of 31 cases in which the nerve was present in tissue sections. The antibody cross reacted with the retinal pigment epithelium (16.5% of cases) and a variety of normal nonocular tissues.