• Experimental sickle cell hyphemas were produced by injecting human sickle cell—β°-thalassemia blood into rabbit anterior chambers. Eyes treated with topical 2% epinephrine hydrochloride showed no significant difference in the duration of the hyphema or in the percentage of sickled cells in the anterior chamber compared with untreated eyes. Topical 2% epinephrine had no apparent sustained effect on intraocular pressure.
Vernot JA, Barron BA, Goldberg MF. Effects of Topical Epinephrine on Experimental Sickle Cell Hyphema. Arch Ophthalmol. 1985;103(2):280-283. doi:10.1001/archopht.1985.01050020132036