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To the Editor.
—Serious complications, eg, severe pain, skin necrosis, and sloughing, can occur as a result of fluorescein dye extravasation. In our last 5,840 cases, we have had no cases of extravasation, because we have employed the following technique.We use a 25-gauge scalp vein needle with 0.3 cc of transparent tubing for fluorescein dye injection. We attach the syringe filled with fluorescein dye to one end of the transparent tubing; the other end of the tubing is connected to a needle. We insert the needle (Fig 1) and draw the patient's blood into the tubing just up to, but not quite covering, the hub of the syringe, so that a small air bubble (<1 cm) separates the patient's blood in the tubing from the fluorescein dye in the syringe (Fig 2). At this point, with the room lights on, we slowly inject the blood back into the vein,
Schatz H, Farkas WS. Prevention of Fluorescein Dye Extravasation. Arch Ophthalmol. 1985;103(7):895. doi:10.1001/archopht.1985.01050070021013