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September 1985

Effect of Topical Acyclovir Therapy on Experimental Herpes Simplex Keratouveitis

Author Affiliations

From the Eye Research Laboratory, Ophthalmological Clinic, Catholic University, Leuven, Belgium.

Arch Ophthalmol. 1985;103(9):1389-1392. doi:10.1001/archopht.1985.01050090141050

• Stromal keratitis and associated iritis were produced in rabbit eyes with the intrastromal injection of live herpes simplex virus. Treatment with 3% acyclovir and 2% trifluridine eye ointments was initiated one day after infection and continued for five consecutive days. These therapies significantly suppressed the development of keratouveitis compared with a placebo ointment. The suppressive action of trifluridine ointment on keratouveitis was significantly more pronounced than that of acyclovir ointment.