• An eyelid with freshly applied black eyeliner pigment was examined histologically. X-ray microanalysis of the pigment suspension from the manufacturer's vial indicated that its composition was 98% iron and 2% titanium. Transmission electron microscopic examination disclosed that particles were in the extracellular matrix; intracellular particles were not seen. By light microscopy, implant material was detected in various levels of the dermis and was found in dermal lymphatics as well as within and surrounding a hair follicle. Our study suggests that systemic exposure to the implant material is possible and offers explanations for permanent eyelash loss, which we have seen following this procedure.
Tse DT, Folberg R, Moore K. Clinicopathologic Correlate of a Fresh Eyelid Pigment Implantation. Arch Ophthalmol. 1985;103(10):1515-1517. doi:10.1001/archopht.1985.01050100091026