• Five patients with basal cell carcinoma received fenretinide. Two patients while receiving the drug had evidence of abnormal rod photoreceptor function that reversed rapidly on cessation of therapy. We speculate that fenretinide may interfere with the binding of vitamin A to opsin or with the transport of vitamin A.
Kaiser-Kupfer MI, Peck GL, Caruso RC, Jaffe MJ, DiGiovanna JJ, Gross EG. Abnormal Retinal Function Associated With Fenretinide, a Synthetic Retinoid. Arch Ophthalmol. 1986;104(1):69-70. doi:10.1001/archopht.1986.01050130079024