January 1986

Abnormal Retinal Function Associated With Fenretinide, a Synthetic Retinoid

Author Affiliations

From the Clinical Branch, National Eye Institute (Drs Kaiser-Kupfer, Caruso, and Jaffe), the Dermatology Branch, National Cancer Institute (Drs Peck and DiGiovanna), and the Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute (Dr Gross), National Institutes of Health, Bethesda, Md.

Arch Ophthalmol. 1986;104(1):69-70. doi:10.1001/archopht.1986.01050130079024

• Five patients with basal cell carcinoma received fenretinide. Two patients while receiving the drug had evidence of abnormal rod photoreceptor function that reversed rapidly on cessation of therapy. We speculate that fenretinide may interfere with the binding of vitamin A to opsin or with the transport of vitamin A.