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February 1986

Lymphocyte Subpopulations in Uveitis

Author Affiliations

From the Ocular Oncology Unit, Department of Ophthalmology (Drs Deschênes, Char, and Freeman), the Francis I. Proctor Foundation (Drs Deschênes, Char, and Freeman), and the Immunogenetics and Transplant Laboratory (Dr Garavoy), University of California, San Francisco. Dr Deschênes is the recipient of a McLaughlin fellowship.

Arch Ophthalmol. 1986;104(2):233-236. doi:10.1001/archopht.1986.01050140087026

• We have used a fluorescence-activated cell sorter to study the lymphocyte subpopulations in the intraocular fluids and peripheral blood of 27 patients with uveitis. T lymphocytes predominated in intraocular fluids. A wide variation in the ratio of Leu 3a-positive (helper) cells to Leu 2a-positive (suppressor) cells was found. No correlation was seen between the specific lymphocyte subpopulations and the clinical uveitis activity or steroid treatment. A statistically significant correlation was found between T-cell subsets present in aqueous humor and peripheral blood. Many lymphocytes seem to be present in intraocular fluids secondary to a breakdown of the blood-ocular barrier.