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February 1986

Subconjunctival Administration of Ceftazidime in Pigmented Rabbit Eyes

Author Affiliations

From the Departments of Medicine (Drs Shockley and Yannis) and Ophthalmology (Drs Fishman, Aziz, and Jay), Veterans Administration Medical Center and Medical College of Georgia, Augusta.

Arch Ophthalmol. 1986;104(2):266-268. doi:10.1001/archopht.1986.01050140124033

• The ocular kinetics of ceftazidime, a third-generation cephalosporin, were examined in phakic and aphakic pigmented eyes of rabbits following subconjunctival injection (100 mg). Peak ceftazidime concentrations (x̄ ± SE, n = three to five rabbits per determination) were as follows: phakic eyes, 40.2 ± 7.3 mg/L in aqueous humor and 11.2 ± 0.6 mg/L in vitreous humor at one hour; aphakic eyes, 30.5 ± 4.8 mg/L in aqueous humor and 15.8 ± 2.4 mg/L in vitreous humor at one hour. The ability of ceftazidime to eliminate an incipient bacterial infection was also studied. Ten aphakic rabbits received intravitreal injections of 50 colony-forming units (cfu) of Pseudomonas aeruginosa. Six of the ten immediately received a subconjunctival injection of ceftazidime (100 mg). At 48 hours following injections, four of four control eyes yielded bacterial counts greater than 6.2 × 106 cfu/mL. Of the six that received ceftazidime, five were sterile and one yielded 10 cfu/mL.