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March 1986

Proton Beam Therapy of Uveal Melanomas

Arch Ophthalmol. 1986;104(3):349-351. doi:10.1001/archopht.1986.01050150049024

Enucleation has long been the usual treatment for malignant uveal melanoma. The advantage of this method in terms of increased life expectancy has been recently challenged,1 and alternative forms of treatment have been used with increased frequency during the past few years.2-8 Photocoagulation2 and local resection3 have been used in selected instances, but radiotherapy remains the most widely used method.4-8

See also p 402.

There are two major radiotherapeutic techniques used in the treatment of uveal melanomas. Radioactive plaques can be sutured on the sclera over the area of the tumor,4-6 and particulate radiation, such as protons8 and helium ions,7 can be used. The advantages of the latter modalities are premised on better dose distributions between tumor and normal tissues. The dose delivered with protons or helium ions can be localized to the tumor more accurately, excluding from the radiation field all

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