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March 1986

Intravitreous Fibronectin and Platelet-Derived Growth FactorNew Model for Traction Retinal Detachment

Author Affiliations

From the Center for Vitreoretinal Research and Pathology Laboratory, The Wilmer Ophthalmological Institute, The Johns Hopkins University, Baltimore.

Arch Ophthalmol. 1986;104(3):417-421. doi:10.1001/archopht.1986.01050150119041

• In proliferative vitreoretinopathy and trauma, traction retinal detachments result from cellular migration into the vitreous cavity with contractile membrane formation. Cleary and Ryan have established the efficacy of intravitreous injection of autologous blood in reproducing this pathologic process in the rabbit eye. It has previously been shown that two serum components, fibronectin and platelet-derived growth factor, stimulate cellular migration. We now show that contractile membranes and traction retinal detachments occur in 72% of rabbit eyes within three weeks following intravitreous injection of fibronectin and plateletderived growth factor. These results provide a straightforward new model to study the development of intravitreous cellular membranes and traction retinal detachments.