To the Editor.
—Glioblastoma multiforme, although the most malignant tumor of glial origin, generally has a low tendency to metastasize; surgical intervention may increase the rate of metastasis. One of the more unusual sites for glioblastoma to spread, despite its proximity, is the orbit. This may occur, however, and must be considered in the context of previously treated disease or a combination of proptosis and altered mental status.
Report of a Case.
—A 30-year-old woman presented with right proptosis and a right medial orbital rim mass that had been present for two weeks. A right frontal glioblastoma had been excised about one year previously, followed by chemotherapy and radiation therapy. A computed tomographic scan two months before presentation showed a normal right orbit. Physical examination revealed a visual acuity of 20/25 in the right eye. There were 4 mm of right proptosis demonstrated by Hertel exophthalmometry, plus 5 mm of
Lawton AW, Karesh JW. Intracranial Glioblastoma Invading the Orbit. Arch Ophthalmol. 1986;104(8):1116-1117. doi:10.1001/archopht.1986.01050200022015