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Article
August 1986

Hypomelanosis of Ito

Arch Ophthalmol. 1986;104(8):1136-1137. doi:10.1001/archopht.1986.01050200042038
Abstract

To the Editor.  —Hypomelanosis of Ito (HI) is a rare neurocutaneous syndrome with pathognomonic cutaneous lesions consisting of bizarre streaks, whorls, and patches of macular hypopigmentation that may present unilaterally or bilaterally any place on the body. The lesions are most easily seen in darkly pigmented individuals; a Wood's light greatly facilitates recognition in fair individuals. Neurologic, ocular, and musculoskeletal abnormalities are frequently a part of HI. Seizures occur in about a third of the patients. At least 42 sporadic cases have been reported since the initial description by Ito in 1952.1,2 To our knowledge, no reports of HI have appeared in the ophthalmic literature, although ocular abnormalities have been noted in at least ten patients in nonophthalmic reports.We describe a patient with HI who had ocular pigment changes similar to those seen in the skin and include a magnetic resonance imaging (MRI) study demonstrating the cerebral

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