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August 1986

Cellular Migration, Proliferation, and ContractionAn In Vitro Approach to a Clinical Problem Proliferative Vitreoretinopathy

Author Affiliations

From the Departments of Ophthalmology (Drs Verdoorn, Renardel de Lavalette, Dalma-Weizhausz, Orr, Sorgente, and Ryan) and Pathology (Dr Sorgente), University of Southern California, Los Angeles; and the Estelle Doheny Eye Foundation, Los Angeles.

Arch Ophthalmol. 1986;104(8):1216-1219. doi:10.1001/archopht.1986.01050200122064

• Presently used animal models of proliferative vitreoretinopathy reflect only cell proliferation and contraction. We used an in vitro model that measured cell migration, proliferation, and contraction. The following four drugs were assayed on this system: daunomycin, taxol, colchicine, and cytochalasin B. Daunomycin was the most effective drug against cell proliferation and cell migration but had no effect on cell contraction; taxol and colchicine affected all three parameters. Cytochalasin B was the least effective drug tested.