• We studied the effect of low-dose colchicine on cell proliferation and migration. Colchicine at doses well below the level of ocular toxicity was found to be a potent inhibitor of astrocyte, fibroblast, and retinal pigment epithelial (RPE) cell proliferation and migration. A colchicine concentration of 1.3 × 10−8 mol/L, 10−8 mol/L, and 1.7 × 10−8 mol/L showed a 50% inhibition of proliferation for RPE, astrocytes, and fibroblasts, respectively. At 10−7 mol/L, colchicine inhibited 44%, 46%, and 93% of RPE, astrocyte, and fibroblast migration, respectively. Lowdose colchicine appears to be an effective inhibitor of RPE, astrocyte, and fibroblast migration and proliferation in vitro.
Lemor M, de Bustros S, Glaser BM. Low-Dose Colchicine Inhibits Astrocyte, Fibroblast, and Retinal Pigment Epithelial Cell Migration and Proliferation. Arch Ophthalmol. 1986;104(8):1223-1225. doi:10.1001/archopht.1986.01050200129066