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Article
October 1986

Human Experimentation: A Guided Step Into the Unknown

Arch Ophthalmol. 1986;104(10):1443. doi:10.1001/archopht.1986.01050220037014

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Abstract

When medical practitioners are faced with critical decisions to make, they may turn to clinical research to help them decide if a new drug or treatment regimen surpasses the old or if a newly developed diagnostic test is safe as well as accurate. Thus, to decide whether to critique a published research article or to design a clinical or preventive trial in a special area of interest, the physician needs to understand research methods. This new book on scientific investigation will help the clinical researcher acquire the perspective needed to understand research principles and design.

"a literate and thought-provoking presentation of what can be a dry topic."

In a concise and lucidly written volume, Dr William Silverman presents a persuasive case for the need for clinical trials in medical research. The author asserts that the randomized clinical trial is necessary to evaluate the efficacy and safety of medical innovations before

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