• Magnetic resonance imaging of the brain was performed on ten patients who had isolated optic neuritis. Seven patients had abnormal images, with a distribution of lesions similar to that seen in multiple sclerosis, demonstrating subclinical dissemination in the central nervous system.
Johns K, Lavin P, Elliot JH, Partain CL. Magnetic Resonance Imaging of the Brain in Isolated Optic Neuritis. Arch Ophthalmol. 1986;104(10):1486-1488. doi:10.1001/archopht.1986.01050220080031