• Vitreous fluorophotometry was performed in young patients (8 to 19 years old) affected by insulin-dependent diabetes mellitus, with no signs of diabetic retinopathy. Oral fluorescein was administered, and measures were used to prevent hypoglycemia during the examination. The results showed a breakdown of the blood-retinal barrier in nine (43%) of the 21 patients. The oral fluorescein method allows a satisfactory evaluation of ocular fluorescence profiles, with minimal risk of systemic side effects.
Nuzzi G, Vanelli M, Venturini I, Bonacini M, Boselli E. Vitreous Fluorophotometry in Juvenile Diabetics After Oral Fluorescein. Arch Ophthalmol. 1986;104(11):1630-1631. doi:10.1001/archopht.1986.01050230068034