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Article
December 1986

Ophthalmoscopic and Histologic Findings in Cytomegalovirus Retinitis Treated With BW-B759U

Author Affiliations

From the Retina Service and the Howe Laboratory of Ophthalmology (Drs D'Amico and Talamo), and the Massachusetts Eye and Ear Infirmary, Department of Ophthalmology (Drs D'Amico, Talamo, and Albert), Harvard Medical School; and the Infectious Disease Unit, Medical Services, Massachusetts General Hospital (Drs Felsenstein, Hirsch, and Schooley), Boston.

Arch Ophthalmol. 1986;104(12):1788-1793. doi:10.1001/archopht.1986.01050240062041
Abstract

• Recent reports have suggested a role for BW-B759U in the treatment of cytomegalovirus retinitis. The present study presents the ophthalmoscopic features in three treated patients, and examines the microscopic findings in the eyes of the first patient ever treated with BWB759U for cytomegalovirus retinitis. Ophthalmoscopic findings of improvement on drug therapy included remission of perivascular infiltration, stabilization of the extent of the retinal area involved, and development of a pigmented chorioretinal scar in the involved area. Relapses occurred with cessation of therapy, and repeated courses of therapy were required. One patient developed a rhegmatogenous detachment with retinal breaks in an atrophic area of treated retinitis. Electron microscopic examination of the eyes of one patient disclosed the persistence of cytomegalovirus inclusions in retinal cells despite previous drug therapy. These findings suggest a virostatic action for BW-B759U.

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