[Skip to Content]
[Skip to Content Landing]
Article
December 1986

Wound Healing After Filtering Surgery in Owl Monkeys

Author Affiliations

From the Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine (Drs Desjardins, Parrish, Nevarez, Heuer, and Gressel), and the Department of Ophthalmology, University of Iowa, Iowa City (Dr Folberg). Dr Desjardins is now with the Department of Ophthalmology, University of Montreal. Dr Nevarez is now with the Department of Ophthalmology, University of Puerto Rico, San Juan. Dr Heuer is now with the Department of Ophthalmology, Southern California School of Medicine and the Estelle Doheny Eye Foundation, Los Angeles. Dr Gressel is now with the Ophthalmology Service, Lorain (Ohio) Community Hospital.

Arch Ophthalmol. 1986;104(12):1835-1839. doi:10.1001/archopht.1986.01050240109050
Abstract

• We performed posterior lip sclerectomies in 29 owl monkey eyes to determine the natural history of wound healing after filtering surgery without adjunctive antimetabolite therapy. We noted three phases of wound healing during clinical and histologic examination: early healing (days 2 to 6), intermediate healing (days 7 to 9), and late healing (days 10 to 14). In the early healing phase, all limbal fistulas except one remained open gonioscopically, but by day 6, fibroblasts had proliferated along the walls of the opening. Proliferation and migration of fibroblasts continued during the intermediate healing phase to completely occlude four and to partially occlude two of the ten fistulas in the eyes studied during this time. In the late healing phase, the limbal fistula was completely closed by granulation tissue in four of five eyes and was slitlike open in one eye. In this model of filtering surgery, wound healing at the sclerectomy site with obliteration of the limbal opening by proliferating fibroblasts occurred within the first 14 postoperative days. We believe that the short-term effects of newer treatments designed to alter wound healing after filtering surgery may be assessed in this model, which is characterized by predictable and prompt wound healing.

×