• Disc swelling and hemorrhages appeared in three eyes of two men receiving amiodarone hydrochloride for cardiac arrhythmias. The initial diagnosis was ischemic optic neuropathy, but visual acuity was preserved, and visual field changes were present in only one eye. Amiodarone is a cationic amphiphilic compound, and other drugs with this property have keratopathy, retinopathy, and optic neuropathy as side effects. We believe our patients had an amiodarone-induced papillopathy.
Gittinger JW, Asdourian GK. Papillopathy Caused by Amiodarone. Arch Ophthalmol. 1987;105(3):349-351. doi:10.1001/archopht.1987.01060030069028