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May 1987

Metoclopramide as Prophylaxis for Nausea and Vomiting Induced by Fluorescein

Author Affiliations

From the Department of Ophthalmology, Truman Medical Center, University of Missouri at Kansas City School of Medicine.

Arch Ophthalmol. 1987;105(5):658-659. doi:10.1001/archopht.1987.01060050076041

• Fluorescein angiography carries with it a variable incidence of nausea and vomiting. We investigated a method of prophylaxis against this side effect. One hundred patients undergoing fluorescein angiography were pretreated in a doublemasked, randomized fashion with either 20 mg of intravenous metoclopramide hydrochloride or an equal volume of normal saline soution. The metoclopramidetreated group demonstrated a statistically significant decrease in the incidence of nausea and vomiting. Eleven (22%) of the control group and three (6%) of the metoclopramide-treated group had this complication. Metoclopramide is an effective drug when used prophylactically in selected patients undergoing fluorescein angiography.