To the Editor.
—We read with interest the recent contribution of Ogura et al,1 which suggested that vitreous fluorophotometry may assist in studying vitreous degeneration in conditions such as retinitis pigmentosa (RP). While most attention has been paid to the more obvious retinal changes in this condition, it was reported in the Archives over 50 years ago that patchy thickening of the internal limiting membrane may occur in RP, followed by separation of the posterior hyaloid from the retina and, rarely, by neovascularization and retinal detachment.2 We agree with Ogura and colleagues that the exact relationship between the retinal disease and the vitreous degeneration remains to be determined. However, we suggest that the finding of a fluorescein concentration gradient (as defined) of 0 mm−1 is in keeping with vitreous detachment, which was not excluded in the patients studied. As shown previously in patients with RP,3 increasing
Plehwe WE, Kohner EM. Vitreous Fluorophotometry in Vitreous Degeneration. Arch Ophthalmol. 1987;105(8):1019. doi:10.1001/archopht.1987.01060080017009