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October 1987

Corneal Ulceration Caused by Penicillin-Resistant Neisseria gonorrhoeae

Author Affiliations

Liverpool, England

Arch Ophthalmol. 1987;105(10):1325-1326. doi:10.1001/archopht.1987.01060100027012

To the Editor.  —Corneal ulceration due to penicillin-resistant Neisseria gonorrhoeae is described. The organism demonstrated a slow growth pattern with high virulence. The bacteriologie workup is discussed in the context of currently available techniques.

Report of a Case.  —A 21-year-old man presented to St Paul's Eye Hospital, Liverpool, England, in June 1986 with purulent conjunctivitis in his right eye. The conjunctiva and eyelids were moderately chemosed and the cornea showed diffuse punctate epithelial keratitis. Bacterial, chlamydial, and herpes simplex virus swabs were taken. Gram's stain showed occasional gram-negative cocci/bacilli and polymorphe. Haemophilus inftuenzae or Pseudomonas aeruginosa was tentatively thought to be the causative organism. Treatment was started with drops of gentamicin sulfate, 3000 U/mL, and penicillin G sodium, 20000 U/mL, in the right eye and floxacillin sodium, 250 mg four times daily orally. The patient's condition deteriorated, with the development of a central superficial corneal ulcer three days after the

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