To the Editor.
—Angioid streaks are a well-recognized complication of homozygous sickle cell disease and affected approximately 40% of patients with sickle cell disease aged 45 years or older in one Jamaican study.1 The streaks were observed to develop during prospective studies at approximately ages 25 and 28 years in two Jamaican patients but are rare before the age of 25 years. The prognosis for angioid streaks in patients with sickle cell disease also appears to be benign; macular involvement with disciform degeneration occurred in only two of 21 Jamaican patients with angioid streaks, at ages 44 and 47 years. Indeed, it has been suggested that neovascularization is generally less prone to develop in black patients with other predisposing conditions, eg, age-related macular degeneration and ocular histoplasmosis.The occurrence and treatment of subretinal neovascularization with angioid streaks in a 21-year-old Jamaican woman with sickle cell disease is therefore of
Moriarty BJ, Webb DK, Serjeant GR. Treatment of Subretinal Neovascularization Associated With Angioid Streaks in Sickle Cell Retinopathy. Arch Ophthalmol. 1987;105(10):1327-1328. doi:10.1001/archopht.1987.01060100029015