• A woman was diagnosed as having a benign lacrimal gland mass at age 23 years and no treatment was advised. About 60 years later, the previously stationary proptosis began to increase, and biopsy specimens demonstrated a malignant mixed tumor (pleomorphic adenocarcinoma) of the lacrimal gland. The patient was subsequently treated with orbital exenteration. From the clinical history and histopathologic findings, it appears that the patient harbored a long-standing pleomorphic adenoma (benign mixed tumor) that gave rise to a pleomorphic adenocarcinoma after remaining stationary for 60 years.
Shields JA, Shields CL. Malignant Transformation of Presumed Pleomorphic Adenoma of Lacrimal Gland After 60 Years. Arch Ophthalmol. 1987;105(10):1403-1405. doi:10.1001/archopht.1987.01060100105037