• Sympathetic ophthalmia was diagnosed 49 months after helium ion irradiation of a left choroidal melanoma. The patient maintained good vision until 18 months after therapy, when she developed neovascular glaucoma. This complication required multiple therapeutic procedures, including topical anti-inflammatory and antiglaucomatous drops, 360° peripheral panretinal cryoblation, and a single 180° application of inferior cyclocryotherapy over a 2½-year period. Four weeks after the cyclocryotherapy, inflammation was noted in both eyes, and, one month later, enucleation of the left sympathogenic eye was performed. Serial histopathologic sections showed a full-thickness, fibrovascular, scleral scar and tantalum marker ring suture without uveal incarceration. Penetrating surgical trauma, a uveal melanoma, and multiple nonpenetrating treatments resulted in the development of sympathetic ophthalmia.
Fries PD, Char DH, Crawford JB, Waterhouse W. Sympathetic Ophthalmia Complicating Helium Ion Irradiation of a Choroidal Melanoma. Arch Ophthalmol. 1987;105(11):1561-1564. doi:10.1001/archopht.1987.01060110107042