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Article
December 1987

Orbital Optic Glioma in NeurofibromatosisMagnetic Resonance Diagnosis of Perineural Arachnoidal Gliomatosis

Author Affiliations

From the Ophthalmic Plastic and Reconstructive Surgery Service and Department of Ophthalmology (Dr Seiff), Neuro-Ophthalmology Unit (Drs Brodsky and Hoyt), Departments of Neurology and Pediatrics (Drs MacDonald and Berg), and Department of Pathology (Dr Howes), University of California Medical Center, San Francisco.

Arch Ophthalmol. 1987;105(12):1689-1692. doi:10.1001/archopht.1987.01060120087032
Abstract

• In a patient with neurofibromatosis and orbital optic glioma, T2-weighted axial magnetic resonance images showed a fusiform area of high signal intensity with a central linear core of lower signal intensity. Computed tomographic images did not show a corresponding variation in tumor density. Histopathologic examination of the tumor revealed dense, circumferential, perineural glial proliferation. This "arachnoidal gliomatosis" is a feature of orbital optic gliomas in neurofibromatosis and, in our magnetic resonance scans, accurately corresponded with the region of high signal intensity within the tumor.

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