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January 1988

Corneal Toxicity of Propamidine

Author Affiliations

From the Department of Ophthalmology, Vanderbilt University Medical Center, Nashville, Tenn.

Arch Ophthalmol. 1988;106(1):68-69. doi:10.1001/archopht.1988.01060130074031

• Two patients with Acanthamoeba keratitis developed a corneal abnormality following prolonged treatment with topical 1% propamidine isethionate. In both instances, withdrawal of drug therapy resulted in a gradual clearing of the keratopathy, with no permanent sequelae. The changes we observed may be confused with those of active Acanthamoeba infection.