• Two patients with Acanthamoeba keratitis developed a corneal abnormality following prolonged treatment with topical 1% propamidine isethionate. In both instances, withdrawal of drug therapy resulted in a gradual clearing of the keratopathy, with no permanent sequelae. The changes we observed may be confused with those of active Acanthamoeba infection.
Johns KJ, Head WS, O'Day DM. Corneal Toxicity of Propamidine. Arch Ophthalmol. 1988;106(1):68-69. doi:10.1001/archopht.1988.01060130074031