To the Editor.
—I read with great interest the study by Robin et al,1 who reported that ALO 2145 (p-aminoclonidine hydrochloride), in a prospective randomized study, minimized acute intraocular pressure (IOP) increase after argon laser iridotomy. However, I am concerned about the manner in which the IOP of patients who entered this study was monitored.According to the report, "applanation tonometry one hour following the instillation of ALO 2145 immediately before laser treatment was not performed." Therefore, although the mean (±SD) IOP in both groups was not significantly different before the administration of the experimental medication (23.6 ± 4.2 mm Hg in eyes treated with ALO 2145 and 20.6 ± 4.0 mm Hg in eyes treated with placebo), we may assume that the IOP, just before laser surgery, in those eyes treated with ALO 2145 may have been significantly lower than that in eyes treated with placebo.This
Fourman S. Effects of Topical ALO 2145 (p-Aminoclonidine Hydrochloride, Aplonidine Hydrochloride) on the Acute Intraocular Pressure Rise After Argon Laser Iridotomy. Arch Ophthalmol. 1988;106(3):307-308. doi:10.1001/archopht.1988.01060130333004