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March 1988

X-linked Retinitis Pigmentosa Profile of Clinical Findings

Author Affiliations

From the Department of Ophthalmology, Eye and Ear Infirmary, University of Illinois College of Medicine at Chicago.

Arch Ophthalmol. 1988;106(3):369-375. doi:10.1001/archopht.1988.01060130395029

• An evaluation of 56 patients with X-linked retinitis pigmentosa revealed a profile of findings that include the following: night blindness within the first two decades of life; spherical refractive errors of −2.00 diopters or greater in addition to an increased prevalence of a cylindrical correction of ± diopters or greater; appreciable impairment of central visual acuity to 20/200 or less by the fifth decade of life; characteristic patterns of field loss; presence of a foveal lesion in up to 75% of the study group; posterior subcapsular lens opacities; and nondetectable electroretinographic amplitudes in more than two thirds of the patients (using conventional full-field recording procedures). These observations are of general value in diagnosis of this disease and for counseling of patients afflicted with this severe form of hereditary night blindness.