• Hemorrhage under the retinal pigment epithelium and neurosensory retina occurred in the temporal periphery of ten patients with aging macular degeneration and one patient with histoplasmosis syndrome. The macula was not the source of bleeding. Peripheral subretinal neovascularization, commonly seen histopathologically, may be the cause. The visual recovery was poor, and most patients failed to regain lost vision once peripheral hemorrhage occurred. The differential diagnosis includes retinal detachment, uveal effusion, hemorrhagic retinoschisis, choroidal melanoma, and metastatic tumor.
Delaney WV, Torrisi PF, Hampton GR, Seigart CR, Hay PB. Hemorrhagic Peripheral Pigment Epithelial Disease. Arch Ophthalmol. 1988;106(5):646-650. doi:10.1001/archopht.1988.01060130700028