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Article
June 1988

Acute Posterior Multifocal Placoid Pigment Epitheliopathy and Cerebral Vasculitis

Author Affiliations

From the Department of Ophthalmology, University of Cincinnati College of Medicine.

Arch Ophthalmol. 1988;106(6):796-800. doi:10.1001/archopht.1988.01060130866042
Abstract

• Four cases of suspected cerebral vasculitis have been described in association with acute posterior multifocal placoid pigment epitheliopathy, but none was confirmed histopathologically. We describe a patient who developed fatal cerebral vasculitis after placoid pigment epitheliopathy. Histopathologic data revealed a focal granulomatous inflammation of medium-sized arteries in the leptomeninges. Multinucleated giant cells were a conspicuous part of the inflammatory reaction. The cause of both placoid pigment epitheliopathy and cerebral vasculitis remains obscure.

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