• A 50-year-old woman was evaluated for a subretinal hemorrhage that extended into the vitreous of the right eye. Examination showed multiple refractile brown spherules in the vitreous. A vitrectomy was performed, and pathologic examination of the spherules showed them to be composed of free hemoglobin. Free-hemoglobin spherulosis in the vitreous, like cholesterosis bulbi, is a manifestation of vitreous hemorrhage.
Grossniklaus HE, Frank KE, Farhi DC, Jacobs G, Green WR. Hemoglobin Spherulosis in the Vitreous Cavity. Arch Ophthalmol. 1988;106(7):961-962. doi:10.1001/archopht.1988.01060140107035