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September 1988

Abnormal Axonemes in X-linked Retinitis Pigmentosa

Author Affiliations

Los Angeles

Arch Ophthalmol. 1988;106(9):1162. doi:10.1001/archopht.1988.01060140322005

To the Editor.  —In their article, published in the March 1988 issue of the Archives, Hunter et al1 state that "attempts to elucidate the pathogeneses of these [genetic] subtypes have been confounded by studies that have considered all patients with RP [retinitis pigmentosa] as a single group," after which two RP studies by my colleagues and I are referenced.Table 1 in our report2 illustrates the great effort the UCLA RP Center takes to subdivide patients with RP on hereditary and test rationale, while our study (their reference 4), which correlated the fluorescein angiographic findings with presence or absence of antiretinal antibodies, also looked at differences between patients with typical rod-cone vs cone-rod RP degeneration (type I vs II RP, Baltimore classification). The authors appear to be critical of the inclusion of patients with RP simplex in studies, yet this group constitutes the greatest percentage of patients with

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