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September 1988

Bilateral Perifoveal Ischemia Associated With Chronic Granulocytic Leukemia

Arch Ophthalmol. 1988;106(9):1170-1171. doi:10.1001/archopht.1988.01060140330018

To the Editor.  —Chronic leukemia can be associated with manifestations involving virtually any structure in the eye or ocular adnexa.1 We report a case of perifoveal ischemia associated with chronic granulocytic leukemia without evidence of peripheral retinal nonperfusion.

Report of a Case.  —A 45-year-old woman with a medical history of chronic granulocytic leukemia of ten years' duration who had been under treatment intermittently with busulfan (5 mg/d) complained of progressive loss of vision in the right eye more than the left of one week's duration. The response to chemotherapy was effective without substantial complication such as pulmonary fibrosis or skin pigmentation. The patient was essentially asymptomatic during the course of treatment except for her visual symptoms.Her ocular examination disclosed a best corrected visual acuity of 20/400 OD and 20/25 OS. Slit-lamp biomicroscopic examination showed the anterior segment to be unremarkable. The optic nerve cup/disc ratio was normal without

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