• A randomized, double-masked study of the effect of terbutaline sulfate, a selective β2-agonist, on the rate of aqueous humor formation was performed in awake and sleeping normal human subjects. The rate of aqueous formation was measured by fluorophotometry. Both the drug- and placebo-treated eyes showed a statistically significant nocturnal reduction of the flow rate (36% suppression in the terbutaline-treated eyes and 43% suppression in the placebo-treated eyes). Terbutaline had no effect on daytime aqueous flow rates, but stimulated flow by 15% during sleep. The drug had no significant effect on intraocular pressure. This study confirms past observations that β-agonists exert their maximal effects during sleep, when endogenous adrenergic stimulation is at a minimum.
Gharagozloo NZ, Larson RS, Kullerstrand LJ, Brubaker RF. Terbutaline Stimulates Aqueous Humor Flow in Humans During Sleep. Arch Ophthalmol. 1988;106(9):1218-1220. doi:10.1001/archopht.1988.01060140378036