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Article
September 1988

Pathogenesis of Epidemic Dropsy Glaucoma

Author Affiliations

From the Department of Ophthalmology (Drs Sachdev, Sood, and Verma), Ocular Pharmacology Section (Dr Gupta), and Ocular Biochemistry Section (Dr Jaffery), Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.

Arch Ophthalmol. 1988;106(9):1221-1223. doi:10.1001/archopht.1988.01060140381037
Abstract

• Thirty-one cases of epidemic dropsy with raised intraocular pressure were studied. Glaucoma was bilateral in all, with open angles and no signs of anterior segment inflammation. The outflow facility was unimpaired (C value, 0.24 ± 0.09 μL/min/mm Hg). Aqueous bioassays revealed significantly elevated prostaglandin E2 level (23.33 ± 4.32 ng/mL) and histamine activity (13.0 ± 2.76 ng/ mL) in all samples from patients with epidemic dropsy glaucoma as compared with negligible levels in control samples from patients with open angle glaucoma. Aqueous biochemical analysis revealed increased total protein level (1.03 ± 0.10 g/L) with a normal globulin pattern as compared with controls (0.26 ± 0.08 g/ L). On histopathologic and histochemical testing, a normal trabecular meshwork was found in 11 of the 12 trabeculectomy specimens. It is concluded that dropsy glaucoma is hypersecretory in nature; prostaglandin and histamine release may have significant roles in its pathogenesis.

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